MTHFR Mutations and Fertility
If I got a dime after time I heard/saw women who were given by their doctor extra folic acid because they have an MTHFR mutation, I would be a millionaire.
But this is beyond sad; it is entirely wrong, from a scientific and medical point of view. I am going to explain what are the MTHFR mutations, why it is sooo bad to prescribe extra folic acid to a patient who has them and what are the solution and precautions. By the end of this article you will feel as upset as I am when you hear that someone with MTHFR mutation has been prescribed extra folic acid.
Make no mistake, this is a topic of monumental importance for fertility, pregnancy and baby health. In my previous article folate vs folic acid, I explained that these two different forms of vitamin B9 are metabolized in a different way and in fact in different organs of the body.
The conversation about MTHFR mutations, has nothing to do with folate or folic acid, because both of these forms of vitamin B9 are inappropriate and potentially dangerous for your fertility and general health.
What are the MTHFR mutations?
Types of MTHFR mutations
There are different MTHFR mutations, which affect more or less this vital conversion of folic acid and folate to methyl-folate.
Two of the most well-studied MTHFR mutations are called C677T and A1298C. Remember that we have two copies of each gene in our DNA; one from the mother and one from the father, so each one of us has two MTHFR genes. If only one of them have the C677T mutation, the precious MTHFR enzyme functions at 70%, but when both copies of the gene have the C677T mutation, then we are left with only 30% of the original capacity to produce methyl-folate.
The A1298C mutation has a lesser impact in methyl-folate production. When both MTHFR genes have this mutation, we preserve a decent 70% of our ability to process folate and folic acid.